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Updated: May 17, 2026
13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
[Kidney damage by antibiotics and chemotherapy]
1S.C. Nefrologia e Dialisi, Ospedale di Cirie', Cirie' (TO) - Italy.
Summary
Antibiotic-induced kidney damage is a significant cause of acute renal failure in hospitals, particularly affecting vulnerable patients. Identifying nephrotoxic antibiotics is crucial for adjusting dosages and preventing kidney injury.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Context:
- Antibiotic-induced kidney damage is a frequent complication in hospital settings.
- It contributes to approximately 10% of acute renal failure cases and 60% of drug-related kidney damage.
- Elderly patients with chronic renal failure, comorbidities, dehydration, or in intensive care units are at highest risk.
Purpose:
- To highlight the prevalence and risk factors associated with antibiotic-induced nephrotoxicity.
- To emphasize the importance of identifying nephrotoxic antibiotics for clinical management.
- To underscore the need for dose adjustments based on renal function and correction of potentiating factors.
Summary:
- The kidney's susceptibility to antibiotic toxicity is influenced by high drug concentrations, elevated blood flow, and a hypoxic environment.
- Various pathogenetic mechanisms can lead to antibiotic-induced kidney damage, affecting all renal structures and causing diverse clinical syndromes.
- Understanding these mechanisms is vital for preventing and managing drug-induced kidney injury.
Impact:
- Facilitates informed clinical decision-making regarding antibiotic selection and dosing.
- Promotes proactive management strategies to mitigate nephrotoxicity in high-risk patient populations.
- Contributes to improved patient outcomes by reducing the incidence and severity of antibiotic-induced kidney damage.
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