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Updated: May 17, 2026
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Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes
Published on: December 15, 2015
Layer-by-layer thin films and microcapsules for biosensors and controlled release.
Katsuhiko Sato1, Shigehiro Takahashi, Jun-ichi Anzai
1Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba, Sendai 980–8578, Japan.
Summary
Layer-by-layer (LbL) deposition creates advanced biosensors and controlled release systems. These films and microcapsules offer tunable properties for enzyme immobilization and pH-responsive insulin delivery.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- Layer-by-layer (LbL) deposition is a versatile technique for fabricating thin films and microcapsules.
- LbL assemblies have shown promise in biosensing and controlled drug delivery applications.
Purpose of the Study:
- To provide an overview of LbL deposited films and microcapsules for biosensors and controlled release.
- To highlight advancements in enzyme immobilization for biosensors and insulin delivery systems.
Main Methods:
- Utilizing LbL deposition with synthetic polymers, binding proteins (avidin, lectin), and polysaccharides.
- Characterizing film permeability and responsiveness to environmental stimuli (e.g., pH).
- Developing glucose-dependent insulin release systems using functionalized LbL microcapsules.
Main Results:
- LbL deposition enables enzyme immobilization on electrodes without loss of activity for biosensors.
- Film properties, including permeability and component choice, can be tuned for biosensor performance and interference elimination.
- pH-sensitive LbL films and microcapsules demonstrate controlled release of insulin, with potential for oral administration.
- Glucose-responsive insulin release systems were constructed using functionalized LbL microcapsules.
Conclusions:
- LbL technology is a powerful platform for developing sophisticated biosensors and advanced controlled release systems.
- The tunability and responsiveness of LbL materials offer significant potential for biomedical applications, including targeted drug delivery and improved diagnostics.
