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Published on: December 9, 2015
Latin American algorithm for treatment of relapsing-remitting multiple sclerosis using disease-modifying agents
Alessandro Finkelsztejn1, Alberto Alain Gabbai, Yara Dadalti Fragoso
1Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre RS, Brazil. alessandro.finkels@gmail.com
Insights
Latin American experts developed new multiple sclerosis (MS) treatment guidelines addressing regional challenges. These evidence-based recommendations improve access to disease-modifying therapies for MS patients in Latin America.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Relapsing-remitting multiple sclerosis (RRMS) affects approximately 50,000 individuals in Latin America.
- Existing European and North American treatment algorithms do not adequately address regional healthcare access and treatment challenges.
Framework:
- The Latin American Multiple Sclerosis Forum, an independent expert group, convened to address these disparities.
- The Forum evaluated scientific evidence on the efficacy and safety of disease-modifying treatments (DMTs).
Implementation:
- Analysis included treatment access and pharmacovigilance programs across eight represented Latin American countries.
- A tailored set of evidence-based guidelines specifically for Latin America was developed.
Implications:
- This initiative provides region-specific recommendations for multiple sclerosis management.
- The guidelines aim to enhance patient access to appropriate and effective DMTs.
- Future perspectives for multiple sclerosis treatment in Latin America were also discussed.
Objective:
It is estimated that circa 50,000 individuals have relapsing-remitting multiple sclerosis in Latin America. European and North-American algorithms for the treatment of multiple sclerosis do not foresee our regional difficulties and the access of patients to treatment.
Methods:
The Latin American Multiple Sclerosis Forum is an independent and supra-institutional group of experts that has assessed the latest scientific evidence regarding efficacy and safety of disease-modifying treatments. Accesses to treatment and pharmacovigilance programs for each of the eight countries represented at the Forum were also analyzed.
Results:
A specific set of guidelines based upon evidence-based recommendations was designed for Latin America. Future perspectives of multiple sclerosis treatment were also discussed.
Conclusions:
The present paper translated an effort from representatives of eight countries discussing a matter that cannot be adapted to our region directly from purely European and North-American guidelines for treatment.
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