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Updated: May 17, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
What should you know about limbic encephalitis?
Sara Machado1, Amélia Nogueira Pinto, Sarosh R Irani
1Neurology Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal. s.jose.11@ucl.ac.uk
Arquivos De Neuro-Psiquiatria
|October 13, 2012
Summary
Autoimmune encephalitis, an inflammatory brain disorder, presents with memory loss and seizures. Early diagnosis and immunotherapy significantly improve the prognosis, even without malignancy.
Area of Science:
- Neurology
- Immunology
Background:
- Autoimmune encephalitis is an inflammatory neurological disorder.
- Characterized by subacute memory impairment, psychiatric symptoms, and seizures.
- Historically considered rare, often paraneoplastic with poor prognosis.
Purpose of the Study:
- To highlight the importance of early recognition of autoimmune encephalitis.
- To emphasize the improved prognosis with prompt immunotherapy.
- To discuss the shift in understanding due to antibody discoveries.
Main Methods:
- Review of recent advancements in autoimmune encephalitis diagnosis.
- Analysis of the impact of membrane-surface directed antibodies.
- Discussion of treatment implications and prognostic factors.
Main Results:
- Recognition of membrane-surface directed antibodies has changed disease understanding.
- Many cases are not associated with malignancy.
- Treatment leads to a good prognosis in a substantial proportion of cases.
Conclusions:
- Early detection and prompt immunotherapy are crucial for favorable outcomes in autoimmune encephalitis.
- The understanding of autoimmune encephalitis has evolved, revealing a more treatable condition.
- Distinguishing autoimmune encephalitis from other neurological disorders is critical for timely intervention.
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