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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Gastric mucosal necrosis with vascular degeneration induced by doxycycline
Shu-Yuan Xiao1, Lei Zhao, John Hart
1Department of Pathology, University of Chicago Medical Center, Chicago, IL 60637, USA. syxiao@uchicago.edu
Abstract:
We encountered 2 patients who underwent esophagogastroduodenoscopy for epigastric abdominal pain, which showed gastric mucosal erosions covered with adherent exudate. Microscopic examination of biopsies from the lesions obtained from the 2 cases revealed characteristic pathologic abnormalities that shared striking similarities. These included superficial mucosal necrosis and capillary vascular degenerative change in a background of reactive or chemical gastropathy. Further review of records identified ongoing oral doxycycline use in both patients. After cessation of the drug both patients' symptoms resolved. A follow-up esophagogastroduodenoscopy in 1 patient showed normal gastric mucosa. This pattern of injury had not been previously described and seems to be characteristic for doxycycline-induced gastric mucosal toxicity. Recognition of the clinical, endoscopic, and pathologic features described here may facilitate prompt diagnosis and management of this condition.
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