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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Using "smart stimulators" to treat Parkinson's disease: re-engineering neurostimulation devices

Julien Modolo1, Anne Beuter, Alex W Thomas

  • 1Bioelectromagnetics, Imaging Program, Lawson Health Research Institute London, ON, Canada ; Department of Medical Biophysics, The University of Western Ontario London, ON, Canada.

Frontiers in Computational Neuroscience
|October 13, 2012
PubMed

Keywords:
Parkinson’s diseasedeep brain stimulationmathematical modelsmedical devicesneuroengineering

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...