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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Related Experiment Video

Updated: May 17, 2026

Home-Based Monitor for Gait and Activity Analysis
07:24

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

Reference values for the 6-Min Walking Test in obese subjects.

Paolo Capodaglio1, Shirley A De Souza, Cinzia Parisio

  • 1Rehabilitation Unit and Laboratory of Research in Biomechanics and Rehabilitation, S Giuseppe Hospital, Istituto Auxologico Italiano IRCCS, Verbania-Piancavallo, Italy.

Disability and Rehabilitation
|October 16, 2012
PubMed
Summary

This study developed a new reference equation for the 6-Minute Walking Test (6MWT) in obese adults. The equation helps assess functional capacity and guide rehabilitation for individuals with obesity.

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Area of Science:

  • Obesity research
  • Clinical exercise physiology
  • Rehabilitation medicine

Background:

  • The 6-Minute Walking Test (6MWT) is a standard functional assessment tool.
  • Existing 6MWT reference equations do not adequately represent obese adult populations.
  • A specific benchmark is needed for evaluating functional capacity in obesity.

Purpose of the Study:

  • To establish a predictive reference equation for the 6-Minute Walking Test (6MWT) in adult obese subjects.
  • To provide a validated tool for assessing functional capacity in obesity.
  • To aid in the planning and monitoring of rehabilitation programs for obese individuals.

Main Methods:

  • 323 obese patients (BMI > 30 kg/m², aged 20-60 years) participated.
  • The 6-Minute Walking Test (6MWT) was performed.
  • Data collected included heart rate, blood pressure, oxygen saturation, anthropometric measurements, and dyspnea level.

Main Results:

  • A novel reference equation was derived: 6MWTm = 894.2177 - (2.0700 × age) - (51.4489 × gender) - (5.1663 × BMI).
  • Age, gender, and BMI significantly correlated with 6MWT distance, explaining 48% of the variance.
  • The equation showed a non-significant average difference between predicted and measured 6MWT values (11.33 ± 52.98 m) with a significant correlation (r = 0.698).

Conclusions:

  • A specific reference equation for the 6-Minute Walking Test (6MWT) in obese adults has been established.
  • This equation serves as a benchmark for assessing functional capacity in rehabilitation settings.
  • It can inform exercise intensity planning and track progress over time for obese patients.