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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

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Subcortical structures in progressive supranuclear palsy: vertex-based analysis.

J Saini¹, B S Bagepally¹, M Sandhya¹

¹Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India.

European Journal of Neurology

|October 16, 2012

Summary

This summary is machine-generated.

Progressive supranuclear palsy (PSP) patients show reduced deep grey matter volumes in the thalamus, hippocampus, pallidum, and brainstem. Advanced MR techniques reveal localized shape changes in these structures, aiding in abnormality detection.

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Area of Science:

Neuroimaging
Neurology
Radiology

Background:

Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
Deep grey matter (GM) structures are affected in PSP.

Purpose of the Study:

To investigate deep GM abnormalities in PSP using MR volumetry and shape analysis.
To identify specific volumetric and shape alterations in PSP patients.

Main Methods:

28 PSP patients and 25 controls underwent 3-tesla MRI.
Automated software extracted volumes of deep GM structures.
Univariate ANCOVA and shape analysis were performed.

Main Results:

PSP patients had significantly lower volumes in bilateral thalami, hippocampus, pallidum, and brainstem.
Shape analysis indicated significant surface reduction in bilateral thalami and the head of the right caudate nucleus.

Conclusions:

MR volumetry and shape analysis detect deep GM abnormalities in PSP.
These techniques are valuable for identifying subcortical structural changes in PSP.