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Recent patents concerning modulators of protein kinase C

Sonia Sanchez-Bautista1, Francisco E Nicolas

  • 1Department of Nursing, Catholic University of Murcia (UCAM), 30107, Murcia, Spain. soniasan@um.es

Recent Patents on DNA & Gene Sequences
|October 16, 2012
PubMed

Insights

This review covers patents on Protein Kinase C (PKC) inhibitors and activators. These novel strategies show promise for treating cancers, inflammatory diseases, and neurodegenerative disorders by modulating PKC signaling pathways.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Protein Kinase C (PKC) is a family of serine/threonine kinases crucial for signal transduction.
  • Dysregulated PKC activity is implicated in various pathologies, including cancer, metastasis, and inflammatory conditions.
  • PKC isoenzymes are involved in diverse diseases such as infarct, transplant rejection, pain, and diabetic macular edema.

Purpose of the Study:

  • To review recent patents on Protein Kinase C (PKC) inhibitors and activators.
  • To highlight novel therapeutic strategies targeting PKC for various diseases.
  • To explore the potential of antisense oligonucleotides and PKC activators in treating specific conditions.

Main Methods:

  • Review of patents related to PKC inhibitors and activators.
  • Inclusion of antisense oligonucleotides targeting PKC and TNF-α.
  • Examination of PKC activators for neurodegenerative disease applications.

Main Results:

  • Patented PKC inhibitors offer a promising approach for preventing and treating PKC-associated diseases.
  • Antisense oligonucleotides represent a viable strategy for infectious and autoimmune diseases linked to misregulated PKC and TNF-α.
  • PKC activators are being investigated for their therapeutic potential in neurodegenerative diseases.

Conclusions:

  • Patent-derived PKC modulators present novel therapeutic avenues for a range of human diseases.
  • Targeting PKC signaling pathways, through inhibition or activation, holds significant clinical potential.
  • Further research into these patented strategies could lead to advanced treatments for cancer, inflammatory, and neurodegenerative conditions.

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