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Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer

Ruby Yun-Ju Huang1, Vin Yee Chung, Jean Paul Thiery

  • 1Department of Obstetrics & Gynaecology, National University Hospital, Singapore. ruby_yj_huang@nuhs.edu.sg

Current Drug Targets
|October 16, 2012
PubMed

Insights

Epithelial ovarian cancer (EOC) is a deadly gynecologic malignancy. Targeting epithelial-mesenchymal transition (EMT) presents a promising therapeutic strategy to improve patient outcomes by combating cancer aggressiveness.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Cancer Biology

Background:

  • Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy.
  • The discovery of novel therapeutic strategies is crucial for improving patient outcomes.
  • Epithelial-mesenchymal transition (EMT) is increasingly recognized for its role in EOC aggressiveness.

Purpose of the Study:

  • To highlight the significance of epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (EOC).
  • To underscore the potential of targeting EMT as a therapeutic strategy for EOC.

Main Methods:

  • Review of emerging evidence on the role of EMT in EOC.
  • Analysis of EMT's contribution to cancer cell migration, invasion, chemoresistance, and stem cell populations.

Main Results:

  • EMT significantly contributes to the aggressive nature of EOC.
  • EMT enhances cancer cell migration and invasion.
  • EMT is associated with chemoresistance and the expansion of cancer stem cell populations in EOC.

Conclusions:

  • Epithelial-mesenchymal transition (EMT) is a key driver of epithelial ovarian cancer (EOC) aggressiveness.
  • Targeting EMT offers a promising therapeutic avenue for improving clinical outcomes in EOC patients.

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