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Updated: May 17, 2026
12:03
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Novel antimicrobial agents against multi-drug-resistant gram-negative bacteria: an overview
George Karras1, Venetia Giannakaki, Vasilios Kotsis
1The Academic Suite, Level 8, Block C, The Wollongong Hospital, Wollongong NSW 2500, Australia.
Recent Patents on Anti-Infective Drug Discovery
|October 16, 2012
Summary
New antimicrobial agents are urgently needed to combat rising multi-drug-resistant Gram-negative bacteria. Several novel compounds in development show promise for treating infections caused by these challenging pathogens.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Multi-drug-resistant Gram-negative bacteria pose a growing global health threat.
- There has been a lack of novel antimicrobial agents for clinical use in recent years.
- Pan-resistant strains of key pathogens like Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa have emerged.
Purpose of the Study:
- To review novel antimicrobial compounds in development for treating multi-drug-resistant Gram-negative bacteria.
- To discuss compounds with potentially new mechanisms of action.
- To explore associated patent landscapes.
Main Methods:
- Literature review of emerging antimicrobial compounds.
- Analysis of scientific publications and patent databases.
- Focus on compounds targeting Gram-negative pathogens.
Main Results:
- Several novel compounds are in various stages of development.
- Some compounds exhibit mechanisms of action distinct from existing antibiotics.
- Patents related to these novel agents have been identified.
Conclusions:
- Promising novel antimicrobial agents are progressing through development pipelines.
- These new compounds offer potential solutions for treating difficult Gram-negative infections.
- Further research and development are crucial to bring these agents to clinical practice.
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