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A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
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[Effects of anesthesia and surgery on certain parameters of humoral immunity]

J P Girard, M Cuevas

    Annales De L'Anesthesiologie Francaise
    |January 1, 1977
    PubMed

    Research on certain parameters of humoral immunity was undertaken in 10 patients who had undergone a major surgical operation. The control subjects were chosen among 10 subjects in good health. The tests were carried out within 24-72 hours after the operation. The determination of cytolytic lymphocyte activity, in the presence of specific antibodies, was strongly lowered in the postoperative period. This was also the case with the capacity to form EAC lymphocyte rosettes. Finally total serum complement was lowered significantly whereas factor C3 remained normal. These results show a change in humoral immunity in the postoperative period together with a reduction in complement activity.

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