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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

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Related Experiment Video

Updated: May 17, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Developmental current and future therapy for severe asthma.

Yutaka Nakamura1

  • 1Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan. ICB75097@nifty.com

Inflammation & Allergy Drug Targets
|October 16, 2012
PubMed
Summary
This summary is machine-generated.

New biologic therapies targeting immune responses show promise for severe asthma. While some trials faced setbacks, understanding cytokine pathways offers new hope for personalized asthma treatments.

Related Experiment Videos

Last Updated: May 17, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Immunology
  • Pulmonology
  • Pharmacology

Background:

  • Severe or refractory bronchial asthma affects 5-10% of patients, showing poor response to standard inhaled corticosteroids.
  • Biopharmaceutical advancements have led to novel therapies targeting key immune cells (Th2-cells) and mediators (cytokines, chemokines).
  • Previous clinical trials with biologics have encountered challenges, leading to study discontinuations.

Purpose of the Study:

  • To review current therapeutic strategies utilizing biological immune response modifiers for asthma.
  • To explore the role of cytokine inhibitors in mitigating pathological immune responses in asthma.
  • To identify potential new approaches for classifying asthma phenotypes.

Main Methods:

  • Review of current literature on biological therapies for severe asthma.
  • Analysis of clinical trial data for biologic agents targeting immune pathways.
  • Examination of the role of cytokines in asthma pathogenesis.

Main Results:

  • Biologics targeting specific immune pathways represent a developing area for severe asthma management.
  • Cytokine inhibitors are crucial tools for understanding disease mechanisms and developing targeted therapies.
  • Elucidating cytokine roles may lead to novel asthma phenotype identification.

Conclusions:

  • Biological therapies offer a promising avenue for managing severe and refractory asthma.
  • Further research into cytokine inhibition is essential for advancing personalized asthma treatment strategies.
  • Identifying distinct asthma phenotypes through immune pathway analysis can improve therapeutic outcomes.