Reprogramming and development in nuclear transfer embryos and in interspecific systems.

Patrick Narbonne1, Kei Miyamoto, J B Gurdon

  • 1The Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom.

Summary

Somatic cell nuclear transfer (SCNT) efficiency is low, but trophectoderm reprogramming is key. Overcoming interspecific incompatibilities in reprogramming systems offers future potential for cloning advancements.

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Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...