Central diabetes insipidus in the setting of acute myelogenous leukemia

We present 2 patients with central diabetes insipidus in the setting of acute myelogenous leukemia (AML). Both patients had months of polyuria and polydipsia compensated by increased fluid intake. Decreased oral intake in the setting of acute illness with continued polyuria led to the development of hypernatremia and the recognition of the underlying diabetes insipidus. Both patients responded well to treatment with desmopressin. Hematologic abnormalities in patients with a diagnosis of central diabetes insipidus should prompt clinicians to consider the possibility of a new AML diagnosis or a relapse in patients with known AML in remission.