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Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

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Cellular reprogramming processes in Drosophila and C. elegans.

¹Berlin Institute for Medical Systems Biology at Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, Berlin 13125, Germany. baris.tursun@mdc-berlin.de

Current Opinion in Genetics & Development

|October 16, 2012

Summary

This summary is machine-generated.

Cellular identity can change naturally during development or be induced. This review explores natural cellular reprogramming in model organisms and factors influencing cell conversion during induced reprogramming.

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Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

Cellular identity is actively maintained but not fixed.
Cell fate can change during normal development and via experimental manipulation.
Understanding cell plasticity is key to developmental processes.

Purpose of the Study:

To review natural cellular reprogramming in model organisms.
To discuss context-dependency in induced cellular reprogramming.
To explore manipulation of cell fate decisions.

Main Methods:

Review of natural reprogramming events in Caenorhabditis elegans and Drosophila melanogaster.
Analysis of ectopic mis-expression of regulatory factors.
Discussion of context-dependent cell conversion.

Main Results:

Natural cellular reprogramming occurs in invertebrates.
Ectopic factors can induce cell identity changes.
Cellular context influences reprogramming outcomes.

Conclusions:

Cellular reprogramming is a fundamental biological process.
Model organisms provide insights into cell fate plasticity.
Targeting cellular context can control cell reprogramming.