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Updated: May 17, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effect of guided bone regeneration with or without pericardium bioabsorbable membrane on bone formation
Yoo-Seok Ahn1, Su-Gwan Kim, Chun-Sung Kim
1Graduate Student, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, GwangJu City, South Korea.
Objective:
The purpose of this study was to evaluate bone formation after using allogeneic bone alone or with a membrane.
Study Design:
Bone graft was performed using the allograft Tutoplast, mineralized cancellous bone allograft, and pericardium in calvarial defects of 60 rats. Rats were divided in 3 groups: control group (no bone graft), group 1 (bone graft without membrane), and group 2 (bone graft with membrane).
Results:
The most new bone formation occurred in group 2. After 6 weeks, group 2 showed infiltration of inflammatory cells, and inflammatory cells were still observed after 12 weeks. The membrane remained even after 12 weeks, and the membrane facilitated bone regeneration by blocking connective tissue.
Conclusions:
The membrane facilitated new bone formation by inhibiting connective tissue invasion.
