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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: May 17, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Early bone mineral density decrease is associated with FSH and LH, not estrogen.

Xi-Yu Wu1, Shan-Jiang Yu, Hong Zhang

  • 1Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 16, 2012
PubMed
Summary
This summary is machine-generated.

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, not estrogen (E2), are linked to early bone mineral density (BMD) loss in Chinese women, impacting menopause bone health.

Related Experiment Videos

Last Updated: May 17, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Gerontology

Background:

  • Uncertainty exists regarding the primary drivers of early bone mineral density (BMD) decline in Chinese women.
  • Investigating the roles of gonadotropins and estrogen in menopausal bone loss is crucial for targeted interventions.

Purpose of the Study:

  • To determine whether follicle-stimulating hormone (FSH), luteinizing hormone (LH), or estradiol (E2) is responsible for the early decrease in BMD among Chinese women.
  • To elucidate the relationship between hormonal levels and bone mineral density decrease rates (BDRs) in this population.

Main Methods:

  • A cross-sectional study involving 368 healthy Chinese women aged 35-60 years.
  • Measurement of bone mineral density (BMD), calculation of BMD decrease rates (BDRs).
  • Assessment of serum levels of FSH, LH, and estradiol (E2).

Main Results:

  • Significant negative correlations were observed between BDR and serum FSH (r=-0.429 to -0.622) and LH (r=-0.359 to -0.526).
  • These negative correlations persisted after adjusting for age and body mass index.
  • Serum FSH was identified as a negative determinant of BDR, while E2 showed a weak positive association in specific skeletal areas.

Conclusions:

  • Menopausal bone mineral density (BMD) decrease in Chinese women is primarily associated with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.
  • Estradiol (E2) does not appear to be the main factor driving early BMD loss in this demographic.