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Anisomycin infusions in the parabrachial nucleus and taste neophobia
Jian-You Lin1, Leslie Renee Amodeo, Joe Arthurs
1Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA. jlin2@uic.edu
Abstract:
To investigate whether de novo protein synthesis in the parabrachial nucleus (PBN) is required for recovery from taste neophobia, anisomycin (a protein synthesis inhibitor) was infused immediately after consumption of a novel saccharin solution (Experiment 1). Unexpectedly, this PBN treatment caused a reduction in saccharin intake. In addition, we found that the anisomycin-induced suppression of tastant intake was attenuated by prior intra-PBN infusions of lidocaine (Experiment 2). This pattern of results raises concerns about using anisomycin to investigate memory consolidation processes in the PBN. Thus, a different manipulation may be needed to examine the nature of the neuroplastic changes that occur in the PBN during taste memory formation.
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