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CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?

Joshua D Ooi1, A Richard Kitching

  • 1Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.

Kidney International
|October 16, 2012
PubMed

Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.

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