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Mean platelet volume may be elevated in mitral valve prolapse and associated with the severity of prolapse

Atilla Icli1, Fatih Aksoy, Abdullah Dogan

  • 11Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 16, 2012
PubMed

Insights

Platelet activation, indicated by elevated mean platelet volume (MPV), may contribute to thromboembolic events in patients with mitral valve prolapse (MVP). Higher MPV in MVP patients correlates with increased mitral regurgitation and leaflet thickening.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Thromboembolic events are a known complication in patients with mitral valve prolapse (MVP).
  • The role of platelet activation in these events within the MVP population remains unclear.
  • Mean platelet volume (MPV) is a potential indicator of platelet activation.

Purpose of the Study:

  • To investigate mean platelet volume (MPV) levels in patients with mitral valve prolapse (MVP).
  • To determine the association between MPV and the severity of MVP, including mitral regurgitation and leaflet morphology.

Main Methods:

  • A comparative study involving 312 patients diagnosed with MVP and 240 healthy control participants.
  • Linear regression analysis was employed to assess the relationship between MPV and echocardiographic parameters of MVP severity.

Main Results:

  • Patients with MVP exhibited significantly higher mean platelet volume (MPV) compared to control participants (8.9 ± 0.7 fL vs. 7.9 ± 0.6 fL, P = .001).
  • MPV was found to be independently associated with the degree of mitral regurgitation (β = .23, P = .001), maximal leaflet displacement (β = .24, P = .001), and the thickness of both anterior (β = .47, P = .001) and posterior leaflets (β = .22, P = .02).

Conclusions:

  • Mean platelet volume (MPV) is elevated in patients with mitral valve prolapse (MVP).
  • Elevated MPV is independently associated with key indicators of MVP severity, suggesting a potential role in disease progression or complications.
Keywords:
mean platelet volumemitral valve prolapseplatelet activationthrombus

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