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Morning glory syndrome: a histopathological study
1Institute of Pathology, Erasmus University, Rotterdam, The Netherlands.
The British Journal of Ophthalmology
|January 1, 1990
Summary
Morning Glory Syndrome involves optic nerve displacement and atrophy, often with other eye anomalies. Histopathology indicates it is not caused by a neuroectodermal closure defect.
Area of Science:
- Ophthalmology
- Developmental Biology
- Histopathology
Background:
- Morning Glory Syndrome is a rare congenital anomaly affecting the optic nerve.
- Understanding its etiology is crucial for diagnosis and management.
Observation:
- A case of Morning Glory Syndrome presented with axial optic nerve retrodisplacement into a peripapillary scleral ectasia (staphyloma).
- Associated findings included absence of the fibrous lamina cribrosa and optic nerve atrophy.
- Other non-inherent ocular developmental anomalies were also noted.
Findings:
- Histopathological examination revealed an uninterrupted lining of the staphyloma's inner wall by normal retinal pigment epithelium.
- This finding refutes the hypothesis that Morning Glory Syndrome results from a neuroectodermal closure defect.
Implications:
- The findings clarify the pathogenesis of Morning Glory Syndrome.
- This case contributes to the understanding of ocular developmental anomalies.
- Accurate etiological understanding aids in clinical diagnosis and genetic counseling.