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Hepatic volume changes induced by radioembolization with 90Y resin microspheres. A single-centre study
Hojjat Ahmadzadehfar1, Carsten Meyer, Samer Ezziddin
1Department of Nuclear Medicine, University Hospital Bonn Germany, Sigmund-Freud-Strasse 25, Bonn, Germany. hojjat.ahmadzadehfar@ukb.uni-bonn.de
European Journal of Nuclear Medicine and Molecular Imaging
|October 16, 2012
Summary
Radioembolization (RE) of the liver with resin microspheres significantly increases the volume of the contralateral liver lobe. This liver lobe hypertrophy may improve outcomes for patients requiring liver resection.
Area of Science:
- Hepatology
- Interventional Radiology
- Oncology
Background:
- Lobar radioembolization (RE) can cause contralateral liver lobe hypertrophy.
- This hypertrophy may enhance the feasibility of liver resection in patients with limited liver reserve.
Purpose of the Study:
- To evaluate the early volumetric changes in liver lobes and spleen following RE with resin microspheres.
- To assess the potential of RE to induce compensatory liver growth.
Main Methods:
- Retrospective analysis of 24 patients with liver-dominant metastatic disease treated with RE.
- Volumetric assessment of liver lobes and spleen using CT scans before and 4-8 weeks after RE.
Main Results:
- RE led to a significant median increase in contralateral left liver lobe volume (34%, P < 0.001) and a decrease in the treated right liver lobe volume (11%, P = 0.03).
- Spleen volume increased by a median of 17% (P = 0.01).
- Significant left lobe hypertrophy was observed in both groups, with a 70% increase in patients with right lobe-only metastases.
Conclusions:
- RE of the right liver lobe with resin microspheres induces significant contralateral left lobe hypertrophy.
- This induced hypertrophy may facilitate liver resection in select patients with right-sided liver metastases and limited contralateral lobe volume.
