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Updated: May 17, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
Published on: August 20, 2014
Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch
Alla Peselis1, Alexander Serganov
1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Abstract:
Coenzyme B(12) has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B(12) riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique junctional structure with a large ligand-binding pocket tailored for specific recognition of the adenosyl moiety and flanked by structural elements that stabilize the regulatory region and enable control of gene expression.
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