Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and refractory oxide ion...

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...

Mass Spectrometry: Isotope Effect

Mass Spectrometry: Isotope Effect

Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of a molecule is different depending on the specific isotope of its elements involved. As a result, the mass spectrum of the molecule exhibits peaks from the same fragment at multiple positions. The positions of these mass signals depend on the mass differences between isotopes. Furthermore, the intensity of these signals is dependent on the...

Atomic Emission Spectroscopy: Lab

Atomic Emission Spectroscopy: Lab

AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Whole blood selenium concentrations in four free-ranging mammal species from central Scandinavia.

Acta veterinaria Scandinavica·2025

Same author

Elemental content and radionuclide activity of bottom and fly ashes from Municipal Solid Waste Incineration: a time series analysis.

Journal of environmental management·2025

Same author

Patterns and controls of rare earth element (REE) dynamics across a boreal stream network.

Water research·2025

Same author

Reduced contribution of sulfur to the mass extinction associated with the Chicxulub impact event.

Nature communications·2025

Same author

Cytotoxicity and Oxidative Stress Induced by Technology-Critical Elements <i>versus</i> Traditional Metal Contaminants: An <i>In Vitro</i> Bioassay Study.

Environmental science & technology·2025

Same author

'Humans think outside the pixels' - Radiologists' perceptions of using artificial intelligence for breast cancer detection in mammography screening in a clinical setting.

Health informatics journal·2024

Search research articles

Related Experiment Video

Updated: May 17, 2026

High Precision Zinc Isotopic Measurements Applied to Mouse Organs

High Precision Zinc Isotopic Measurements Applied to Mouse Organs

Published on: May 22, 2015

Isotopic analyses by ICP-MS in clinical samples.

Ilia Rodushkin¹, Emma Engström, Douglas C Baxter

¹ALS Scandinavia AB, Aurorum 10, Luleå, Sweden.

Analytical and Bioanalytical Chemistry

|October 16, 2012

Summary

Inductively coupled plasma mass spectrometry (ICP-MS) enables precise isotope abundance ratio measurements in clinical samples for exposure monitoring, human provenancing, and metabolic research. Advances in ICP-MS instrumentation and applications are reviewed, with future development suggestions provided.

More Related Videos

Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Published on: May 1, 2017

Related Experiment Videos

Last Updated: May 17, 2026

High Precision Zinc Isotopic Measurements Applied to Mouse Organs

High Precision Zinc Isotopic Measurements Applied to Mouse Organs

Published on: May 22, 2015

Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Published on: May 1, 2017

Area of Science:

Analytical Chemistry
Environmental Science
Clinical Chemistry

Background:

Isotope abundance ratio measurements are crucial for diverse clinical and environmental applications.
Inductively coupled plasma mass spectrometry (ICP-MS) is a powerful technique for these measurements.
Existing reviews lack a comprehensive focus on recent ICP-MS applications in clinical contexts.

Purpose of the Study:

To critically review ICP-MS applications for isotope abundance ratio measurements in clinical samples.
To highlight applications in occupational/environmental exposure, human provenancing, and metabolic research.
To discuss recent instrumentation advances and future directions in the field.

Main Methods:

Review of recent advances in ICP-MS instrumentation.
Analysis of selected examples of ICP-MS applications.
Focus on isotope dilution, tracer studies, and natural/man-made isotope variations.

Main Results:

ICP-MS is highly effective for accurate analyte quantification using isotope dilution.
Applications include tracer studies in nutrition and toxicology.
Measurements of isotope variations (Pb, Sr, actinides, heavy elements) are vital for exposure and provenance studies.

Conclusions:

ICP-MS is a versatile tool for isotope ratio analysis in clinical and environmental monitoring.
Continued advancements in instrumentation will expand its utility.
Further research is needed to fully leverage ICP-MS for complex biological and environmental questions.