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Diffuse scaling dermatitis in an athymic nude mouse.

M Russo1, A Invernizzi, A Gobbi

  • 1Pharmacology Department, BU Oncology, Nerviano Medical Sciences, Milan, Italy.

Veterinary Pathology
|October 16, 2012
PubMed
Summary
This summary is machine-generated.

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A mouse with diffuse scaling dermatitis was diagnosed with hyperplastic dermatitis linked to Staphylococcus xylosus, not Corynebacterium bovis. This highlights opportunistic bacterial infections in athymic nude mice.

Area of Science:

  • Veterinary Pathology
  • Microbiology
  • Dermatology

Background:

  • Athymic nude mice (CrTac:NCr-Foxn1(nu)) are valuable research models but can be susceptible to skin conditions.
  • Diffuse scaling dermatitis in mice often presents with gross signs suggestive of Corynebacterium bovis infection (scaly skin disease).

Observation:

  • A 16-week-old female athymic nude mouse presented with diffuse scaling dermatitis.
  • Initial gross examination suggested Corynebacterium bovis infection.
  • Microscopic examination revealed chronic hyperplastic and hyperkeratotic dermatitis with ulcerations, crusts, and Gram-positive coccoid bacteria.

Findings:

  • Corynebacterium bovis was not isolated from affected or unaffected mice.
  • Staphylococcus xylosus was isolated in high numbers from the affected mouse's skin lesions.
Keywords:
Corynebacterium bovisStaphylococcus xylosusathymic nude mouseopportunistic infectionscaling dermatitis

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  • Histopathology confirmed dermatitis and identified intralesional bacteria consistent with Staphylococcus xylosus.

    • Implications:

    • This case rules out Corynebacterium bovis as the causative agent despite initial clinical suspicion.
    • It suggests Staphylococcus xylosus can act as an opportunistic pathogen causing dermatitis in athymic nude mice.
    • Accurate diagnosis requires integrating clinical, histopathological, and microbiological data to identify causative agents and guide treatment.