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Transient receptor potential melastatin 4 and cell death.

J Marc Simard1, S Kyoon Woo, Volodymyr Gerzanich

  • 1Department of Neurosurgery, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD 21201-1595, USA. msimard@smail.umaryland.edu

Pflugers Archiv : European Journal of Physiology
|October 16, 2012
PubMed
Summary

Transient Receptor Potential Melastatin 4 (TRPM4) channels are key in accidental necrosis, a cell death process. Unchecked TRPM4 activation leads to cell rupture, particularly in ATP-depleted cells.

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