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RAD51 polymorphisms and breast cancer risk
Mojgan Hosseini1, Massoud Houshmand, Ahmad Ebrahimi
1Department of Science, Islamshahr Branch, Islamic Azad University, Sayad Shirazi St., Islamshahr, Tehran, Iran. mojgan-Hosseini@iiau.ac.ir
Molecular Biology Reports
|October 16, 2012
Summary
This study investigated the RAD51 G/C polymorphism in Iranian breast cancer patients. The RAD51 GG genotype was identified as a significant risk factor, highlighting its association with increased breast cancer risk.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Breast cancer (BC) is a leading cause of mortality in women globally and ranks second in Iran.
- Genetic predispositions, including specific gene polymorphisms, play a crucial role in breast cancer development.
- The RAD51 gene is involved in DNA repair, making its polymorphisms potential risk factors for cancer.
Purpose of the Study:
- To determine the frequency of the RAD51 G/C polymorphism in Iranian breast cancer patients.
- To evaluate the association between RAD51 G/C polymorphism and breast cancer risk in a sporadic Iranian population.
- To identify specific genotypes that may confer a higher risk of developing breast cancer.
Main Methods:
- A population-based case-control study was conducted with 294 breast cancer cases and 315 controls from Iran.
- Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay was used to analyze RAD51 G/C polymorphisms.
- Statistical analyses, including odds ratios and confidence intervals, were performed to assess risk association.
Main Results:
- The homozygote genotype RAD51 GG showed the highest frequency in both patient (33.3%) and control (41.4%) groups.
- The RAD51 GG genotype was found to be a significant risk factor (odds ratio, 2.276; p = 0.001).
- A significant association between breast cancer risk and RAD51 GG and CC polymorphisms was observed.
Conclusions:
- The RAD51 G/C polymorphism, particularly the GG genotype, is significantly associated with an increased risk of breast cancer in the studied Iranian population.
- These findings suggest that RAD51 G/C polymorphism could serve as a potential biomarker for breast cancer risk assessment.
- Further research is warranted to explore the functional implications of these polymorphisms in breast cancer pathogenesis.
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