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Related Experiment Videos

Prosthesis-associated pseudomembrane-induced bone resorption.

A M Appel1, W G Sowder, S W Siverhus

  • 1Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.

British Journal of Rheumatology
|February 1, 1990
PubMed
Summary
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A pseudomembrane at the implant site causes bone loss, leading to aseptic loosening of cemented hip implants. This tissue produces inflammatory mediators that trigger bone resorption, contributing to implant failure.

Area of Science:

  • Biomaterials science
  • Orthopedic surgery
  • Immunology

Background:

  • Aseptic loosening is a major cause of cemented hip implant failure.
  • A pseudomembranous tissue forms at the cement-bone interface, associated with loosening.
  • This tissue is thought to be a foreign body reaction to wear debris.

Purpose of the Study:

  • To investigate the role of the pseudomembrane in the bone resorption process.
  • To identify inflammatory mediators produced by the pseudomembrane.
  • To assess the direct effect of pseudomembrane-conditioned media on bone resorption.

Main Methods:

  • Explant cultures of pseudomembrane and synovial tissue from patients undergoing revision surgery.
  • Measurement of interleukin-1, tumor necrosis factor, and prostaglandin E2 production.

Related Experiment Videos

  • Assessment of 45Ca release from prelabeled bone rudiments exposed to conditioned media.

    • Main Results:

    • Pseudomembrane and synovial tissues produced interleukin-1, tumor necrosis factor, and prostaglandin E2.
    • Conditioned media from pseudomembrane cultures induced significant bone resorption.
    • This bone resorption was evidenced by increased 45Ca release.

    Conclusions:

    • The prosthesis-associated pseudomembrane plays a critical role in the pathogenesis of bone resorption.
    • Inflammatory mediators produced by the pseudomembrane contribute to aseptic loosening.
    • Targeting the pseudomembrane may offer a strategy to prevent implant failure.