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TSGene: a web resource for tumor suppressor genes.
Min Zhao1, Jingchun Sun, Zhongming Zhao
1Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Nucleic Acids Research
|October 16, 2012
Summary
Tumor suppressor genes (TSGs) are crucial for preventing cancer. This study introduces TSGene, a database integrating 716 human TSGs with experimental data to aid cancer research.
Area of Science:
- Genomics
- Cancer Biology
- Bioinformatics
Background:
- Tumor suppressor genes (TSGs) regulate cell proliferation, cell-cycle checkpoints, and apoptosis, acting as critical guardians against cancer.
- Non-coding RNAs are increasingly recognized for their tumor-suppressive roles, highlighting the need for comprehensive gene resources.
- Investigating tumorigenesis requires integrated data on TSGs, including gene expression and epigenetic signatures.
Purpose of the Study:
- To develop a comprehensive, literature-based database of tumor suppressor genes (TSGs).
- To integrate TSGs with large-scale experimental evidence for cancer research.
- To provide a valuable resource for investigating TSGs and their molecular mechanisms in cancer.
Main Methods:
- Developed TSGene, a literature-based database of tumor suppressor genes.
- Curated TSG information from UniProtKB, the Tumor Associated Gene database, and PubMed abstracts.
- Integrated data including gene expression, epigenetic signatures, mutations, and regulatory interactions.
Main Results:
- TSGene database currently contains 716 human (637 protein-coding, 79 non-coding), 628 mouse, and 567 rat TSGs.
- Detailed annotations for each TSG include cancer mutations, gene expression, methylation sites, transcription factor regulations, and protein-protein interactions.
- The database is freely available at http://bioinfo.mc.vanderbilt.edu/TSGene/.
Conclusions:
- TSGene provides a comprehensive resource for the study of tumor suppressor genes.
- The integrated data facilitates further investigation into the molecular mechanisms of tumorigenesis.
- This database supports research on cancer biology and the development of targeted therapies.
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