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Updated: May 17, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Design, development and optimization of self-microemulsifying drug delivery system of an anti-obesity drug
Jagruti Desai1, Nirav Khatri, Sachin Chauhan
1Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajorao University of Baroda, Kalabhavan, Vadodara, Gujarat, India.
Abstract:
The aim of the present work was to formulate a self-microemulsifying drug delivery system (SMEDDS) containing orlistat. The oil, surfactant and co-surfactant were decided based on the solubility studies. Pseudoternary phase diagrams were plotted, microemulsification area was determined and different formulations were prepared. Particle size, zeta potential, dispersibility test and thermodynamic stability studies were measured. In-vitro dissolution test of thermodynamically stable formulations OS-B and OS-C were carried and results were compared with those of plain drug and suspension formulation. Stability studies performed indicated that formulation OS-C remained stable over 12 months period. Thus this investigation concluded that hydrophobic drugs like orlistat can be delivered effectively through the formulation of SMEDDS.
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