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Deafferentation in the rat increases mechanical nociceptive threshold in the innervated limbs
V Kayser1, A I Basbaum, G Guilbaud
1Unité de Recherche en Physiopharmacologie du Système nerveux U. 161, INSERM, Paris, France.
Brain Research
|February 5, 1990
Abstract:
In this study in the rat, we evaluated the effect of unilateral, multiple cervical dorsal rhizotomy (C5-T1) on nociceptive thresholds in the unoperated limbs. This was tested by measuring the vocalization threshold to paw pressure. We report that deafferentation by dorsal rhizotomy results in a delayed, but transient increase in mechanical nociceptive thresholds in the 3 innervated limbs.