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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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Host modulation by therapeutic agents.

Sugumari Elavarasu¹, Santhosh Sekar, Thamaraiselvan Murugan

¹Department of Periodontics, JKKN Dental College, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences

|October 16, 2012

Summary

Individuals prone to periodontal disease experience severe breakdown despite excellent oral hygiene. Host modulation therapies target destructive enzymes and inflammatory mediators to restore normal levels, offering a new treatment approach.

Keywords:

Cytokines Matrix metalo protienases (MMP)Periodontitis

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Area of Science:

Periodontology
Biochemistry
Pharmacology

Background:

Periodontal disease can cause advanced breakdown even with meticulous oral hygiene.
Destructive enzymes and inflammatory mediators are key factors in periodontal destruction.
Elevated levels of these mediators are observed during active periodontal disease.

Purpose of the Study:

To explore host modulation as a therapeutic strategy for periodontal disease.
To identify agents that can normalize destructive enzymes and inflammatory mediators.
To provide an overview of current and potential host modulation therapies.

Main Methods:

Literature review of therapeutic agents with host modulation properties.
Analysis of the role of enzymes and mediators in periodontal destruction.
Categorization of various pharmacological and biological agents.

Main Results:

Several therapeutic agents demonstrate host modulation properties.
These agents include doxycycline, NSAIDs, bisphosphonates, and biologics.
Targeted inhibition of enzymes and mediators is a promising approach.

Conclusions:

Host modulation offers a novel strategy for managing periodontal disease.
Targeting specific enzymes and inflammatory pathways can mitigate disease progression.
Further research into these agents can lead to improved treatment outcomes.