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Updated: May 17, 2026

The Establishment of a Murine Maxillary Orthodontic Model
04:11

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Published on: October 27, 2023

NSAIDs in orthodontic tooth movement.

Muthukumar Karthi1, Gobichettipalyam Jagtheeswaran Anbuslevan, Kullampalyam Palanisamy Senthilkumar

  • 1Department of Orthodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences
|October 16, 2012
PubMed
Summary

Pain relievers like NSAIDs can slow orthodontic tooth movement. Acetaminophen is recommended for managing orthodontic pain as it does not impede tooth movement, unlike NSAIDs.

Keywords:
AcetaminophenNSAIDsprostaglandins

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Area of Science:

  • Orthodontics
  • Pharmacology
  • Biomedical Engineering

Background:

  • Orthodontic tooth movement is a biological process driven by mechanical forces.
  • These forces cause pressure and tension in the periodontal ligament and alveolar bone, leading to socket remodeling.
  • Pain management is common during orthodontic treatment, with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) frequently prescribed.

Purpose of the Study:

  • To evaluate the impact of commonly prescribed pain medications on orthodontic tooth movement.
  • To identify pain management strategies that do not compromise treatment efficacy.

Main Methods:

  • Review of literature on the biological mechanisms of orthodontic tooth movement.
  • Analysis of the pharmacological effects of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and acetaminophen on prostaglandin synthesis and bone resorption.
  • Comparison of the effects of various analgesics on tooth movement in orthodontic contexts.

Main Results:

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) inhibit prostaglandin synthesis, which plays a role in bone resorption, potentially slowing tooth movement.
  • Commonly prescribed NSAIDs include aspirin, ibuprofen, diclofenac, valdecoxib, and celecoxib.
  • Acetaminophen manages orthodontic pain effectively without negatively impacting the rate of tooth movement.

Conclusions:

  • Acetaminophen is the preferred analgesic for managing pain associated with orthodontic treatment.
  • Avoiding NSAIDs during orthodontic treatment is advisable to prevent interference with tooth movement efficacy.