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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Applications of immunohistochemistry.

Journal of pharmacy & bioallied sciences·2012

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Microarray and its applications.

Rajeshwar Govindarajan¹, Jeyapradha Duraiyan, Karunakaran Kaliyappan

¹Department of Oral and Maxillofacial Pathology, JKK Nataraja Dental College and Hospital, Komarapalayam, Namakkal, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences

|October 16, 2012

Summary

Microarray technology aids cancer research and pharmacological treatments for diseases like oral lesions. While currently limited in dentistry, its affordability may increase future applications in analyzing tumor markers.

Keywords:

Cancer human genome microarray tissue microarray

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Area of Science:

Biotechnology
Genomics
Cancer Research

Background:

Microarray technology represents a significant advancement in analyzing biological samples.
Its application in cancer research aids in understanding disease mechanisms and developing targeted therapies.
Current use in dentistry is limited but shows potential for growth.

Purpose of the Study:

To discuss the techniques and applications of microarray technology.
To highlight its role in cancer research and pharmacological approaches.
To explore its potential future use in dentistry.

Main Methods:

Review of existing microarray techniques.
Analysis of microarray applications in disease research, including oral lesions.
Examination of marker incidence testing in tumors.

Main Results:

Microarrays facilitate the analysis of large sample sets for research.
They assist in identifying specific markers in tumors.
The technology supports pharmacological approaches to disease treatment.

Conclusions:

Microarray technology is a valuable tool in cancer research and drug development.
Its potential in dentistry is significant, particularly as costs decrease.
Further exploration of microarray applications in oral medicine is warranted.