Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Narrative Reviews in Contemporary Medical Literature: An Overview of Current Role and Relevance.

Cureus·2026

Same author

A Narrative Review of Teledentistry in the AI Era: Scope, Opportunities, and Future Prospects in India.

Cureus·2026

Same author

Oral Manifestations of Prediabetes: A Narrative Review of an Early Diagnostic Window for Dental Practice.

Cureus·2026

Same author

Scope and Prospects of Social Media for Patient Education and Engagement in Medical Practice.

Cureus·2026

Same author

Retrocuspid Papillae of the Gingiva: Clinical Nature and Controversies.

Cureus·2026

Same author

Effect of Topical Hyaluronic Acid on Wound Healing and Pain Following Electrocautery Frenectomy: A Randomized Controlled Trial.

Cureus·2026

Search research articles

Related Experiment Video

Updated: May 17, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Bisphosphonates: An update.

Nalliappan Ganapathy¹, Subramanium Gokulnathan, Nataraj Balan

¹Department of Oral Pathology, Vivekananda Dental College, Thiruchenkodu, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences

|October 16, 2012

Summary

This summary is machine-generated.

Bisphosphonates treat bone conditions like osteoporosis and metastatic bone lesions by reducing bone resorption. Recent studies highlight potential complications, emphasizing the need for dental awareness regarding these widely used medications.

Keywords:

Bisphosphonate-associated osteonecrosis osteonecrosis osteoporosis

More Related Videos

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Published on: September 9, 2011

Related Experiment Videos

Last Updated: May 17, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Published on: September 9, 2011

Area of Science:

Pharmacology
Bone Biology
Dentistry

Background:

Bisphosphonates are crucial for managing bone conditions, including osteoporosis and metastatic bone lesions.
These drugs effectively modulate bone turnover and inhibit excessive bone resorption.
Increased usage has led to documented complications, necessitating updated knowledge.

Purpose of the Study:

To provide current insights into bisphosphonate characteristics and mechanisms.
To review the pathogenesis of bisphosphonate-related complications.
To highlight the clinical relevance of bisphosphonates for dental professionals.

Main Methods:

Literature review of recent studies on bisphosphonates.
Analysis of drug characteristics, mechanisms of action, and pathogenesis.
Focus on implications for dental practice and patient care.

Main Results:

Bisphosphonates exhibit diverse characteristics and mechanisms targeting bone resorption.
Understanding pathogenesis is key to identifying and managing complications.
Dental practitioners require updated knowledge for safe patient management.

Conclusions:

Bisphosphonates are effective but associated with potential complications.
Dentists must be aware of bisphosphonate use and associated risks.
Further research and clinical vigilance are essential for optimizing patient outcomes.