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Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X

Ying-Chieh Liao1, Kae-Woei Liang, Wen-Jane Lee

  • 1Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|October 17, 2012
PubMed

Insights

Adipokines, such as adiponectin and leptin, may play a role in cardiac syndrome X (CSX). A higher leptin to adiponectin ratio was found to predict CSX in this study.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Cardiac Syndrome X (CSX) is a condition characterized by angina-like chest pain without obstructive coronary artery disease.
  • The underlying mechanisms of CSX are not fully understood, and the role of adipokines has not been previously investigated.

Purpose of the Study:

  • To investigate the association between circulating adipokines and the development of cardiac syndrome X (CSX).
  • To determine if adipokine levels or ratios are predictive of CSX.

Main Methods:

  • Retrospective enrollment of 59 CSX subjects and 54 control subjects with valvular heart disease or arrhythmia.
  • Measurement of adipokines (adiponectin, leptin) using ELISA tests.
  • Multivariate analysis to identify predictors of CSX.

Main Results:

  • CSX subjects exhibited lower adiponectin levels compared to controls.
  • CSX subjects showed higher leptin levels and a significantly higher leptin/adiponectin ratio (p < 0.001).
  • A higher leptin/adiponectin ratio was identified as a predictor of CSX, whereas the insulin-resistance index was not.

Conclusions:

  • Adipokines, specifically the leptin/adiponectin ratio, may be implicated in the pathogenesis of cardiac syndrome X.
  • These findings suggest a potential link between metabolic dysregulation, as indicated by adipokine profiles, and CSX development.
Abstract

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