Quantitative response of IMS detector for mixtures containing two active components
Jarosław Puton1, Sanna I Holopainen, Marko A Mäkinen
1Faculty of Advanced Technology and Chemistry, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland. jputon@wat.edu.pl
Analytical Chemistry
|October 17, 2012
Summary
This study on ion mobility spectrometry (IMS) shows how co-injected compounds affect detector signals. Detection can be improved by analyzing specific ion dimers, even with interfering substances present.
Area of Science:
- Analytical Chemistry
- Spectrometry
Background:
- Ion mobility spectrometry (IMS) is a powerful analytical technique.
- Understanding analyte signal behavior in the presence of co-injected compounds is crucial for accurate detection.
Purpose of the Study:
- To investigate the relationship between IMS detector output signals and the concentrations of simultaneously introduced compounds.
- To evaluate the impact of admixtures on analyte detection and explore strategies for enhanced detection.
Main Methods:
- Simultaneous introduction of compound pairs (DMMP + acetone, MTBE + acetone, TMA + NA) into an IMS reaction section.
- Utilizing a two-channel vapor generator with permeation sources and mass-flow controllers for precise concentration control.
- Analysis of calibration dependencies using a mathematical model of the reaction region.
Main Results:
- Acetone did not affect the signal for dimethyl methylphosphonate (DMMP) dimer ions.
- For methyl tert-butyl ether (MTBE) + acetone and trimethylamine (TMA) + n-nonylamine (NA) pairs, analyte ion peaks decreased with increasing admixture concentration.
- Detection using asymmetric dimer ions (proton-bound molecules of both compounds) proved effective, particularly for TMA in the presence of NA, yielding higher signals than monomer or dimer ions alone.
Conclusions:
- Admixtures can have varied effects on IMS analyte detection.
- Analyzing specific asymmetric dimer ions offers a robust method for detecting analytes in complex mixtures.
- A mathematical model aids in estimating signal intensity based on ionic species and analyte concentration.
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