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Carcinogenicity studies with deltamethrin in mice and rats
J R Cabral1, D Galendo, M Laval
1International Agency for Research on Cancer, Unit of Mechanisms of Carcinogenesis, Lyon, France.
Cancer Letters
|February 1, 1990
Summary
This study investigated the carcinogenic potential of the synthetic pyrethroid pesticide Deltamethrin in mice and rats. While some tumors were observed, Deltamethrin did not show clear carcinogenic effects in these long-term animal studies.
Area of Science:
- Toxicology
- Environmental Health
- Carcinogenesis Research
Background:
- Deltamethrin is a widely used synthetic pyrethroid insecticide.
- Assessing the long-term health effects, specifically carcinogenicity, of pesticides is crucial for public health and environmental safety.
Purpose of the Study:
- To evaluate the carcinogenic potential of Deltamethrin through long-term exposure studies in rodent models.
- To determine if Deltamethrin poses a cancer risk to mammals.
Main Methods:
- Two-year carcinogenicity bioassays were conducted on mice and rats.
- Animals were administered Deltamethrin via gavage at various dose levels (0, 1, 4, 8 mg/kg for mice; 0, 3, 6 mg/kg for rats) in arachis oil.
Main Results:
- In mice, an increased incidence of lymphomas was observed at 1 and 4 mg/kg Deltamethrin, but not at 8 mg/kg.
- In rats, an increased incidence of thyroid tumors was noted, though without a clear dose-response relationship.
- No definitive carcinogenic activity was established for Deltamethrin in either species under the study conditions.
Conclusions:
- Deltamethrin did not demonstrate clear carcinogenic activity in mice or rats in this two-year study.
- Further research is warranted on Deltamethrin and related pyrethroid compounds to fully understand their long-term toxicological profiles.