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HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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[G-protein-coupled receptors dimers and oligomers: for which purpose? The GABA(B) receptor under investigation]

Julie Kniazeff1, Jean-Philippe Pin

  • 1Institut de génomique fonctionnelle, universités Montpellier 1 et 2, Montpellier Cedex 5, France. julia.kniazeff@igf.cnrs.fr

Medecine Sciences : M/S
|October 17, 2012
PubMed

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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