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Updated: May 17, 2026

Micro-scale Engineering for Cell Biology
Published on: October 1, 2007
BioModel engineering for multiscale Systems Biology
1Department of Computer Science, Brandenburg University of Technology, Postbox 10 13 44, 03013 Cottbus, Germany. monika.heiner@informatik.tu-cottbus.de
Abstract:
We discuss some motivational challenges arising from the need to model and analyse complex biological systems at multiple scales (spatial and temporal), and present a biomodel engineering framework to address some of these issues within the context of multiscale Systems Biology. Our methodology is based on a structured family of Petri net classes which enables the investigation of a given system using various modelling abstractions: qualitative, stochastic, continuous and hybrid, optionally in a spatial context. We illustrate our approach with case studies demonstrating hierarchical flattening, treatment of space, and hierarchical organisation of space.
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