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Skin lesions in histoplasmosis

Patricia Chang1, Cecilia Rodas

  • 1Department of Dermatology, Hospital General de Enfermedades del Instituto Guatemalteco de Seguridad Social, 9a calle 7-55 zona 9, 01009, Guatemala. pchang2622@gmail.com

Clinics in Dermatology
|October 17, 2012
PubMed

Insights

Histoplasmosis, a fungal infection, commonly affects the lungs but can cause diverse skin lesions in AIDS patients. These cutaneous manifestations range from papules and ulcers to more severe conditions like pyoderma gangrenosum.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Histoplasmosis is a granulomatous infection caused by the dimorphic fungus Histoplasma capsulatum.
  • It has a worldwide distribution, with prevalence in North and Central America.
  • Pulmonary involvement is the most common presentation.

Purpose of the Study:

  • To describe the range of cutaneous manifestations in patients with disseminated histoplasmosis, particularly those with Acquired Immunodeficiency Syndrome (AIDS).

Main Methods:

  • Review of clinical presentations and literature on histoplasmosis.
  • Analysis of reported skin lesion types in disseminated cases.

Main Results:

  • Cutaneous manifestations occur in 10% to 25% of AIDS patients with disseminated histoplasmosis.
  • Lesions are polymorphic, including papules, plaques, pustules, ulcers, nodules, and dermatitis.
  • Specific presentations can mimic other dermatological conditions like molluscum contagiosum, acne, rosacea, and pyoderma gangrenosum.

Conclusions:

  • Disseminated histoplasmosis in AIDS patients frequently presents with a wide spectrum of skin lesions.
  • Recognizing these diverse dermatological signs is crucial for timely diagnosis and management of Histoplasma capsulatum infection.

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