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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Related Experiment Video

Updated: May 17, 2026

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Advances in stem cell mobilization.

Ibraheem H Motabi1, John F DiPersio

  • 1Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA. imotabi@dom.wustl.edu

Blood Reviews
|October 17, 2012
PubMed
Summary
This summary is machine-generated.

Mobilized peripheral blood stem cells (PBSCs) now replace bone marrow for transplantation. Understanding stem cell trafficking mechanisms can improve mobilization strategies for patients who don't respond well to current G-CSF treatments.

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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
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In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Transplantation Medicine

Background:

  • Mobilized peripheral blood stem cells (PBSCs) are preferred over bone marrow for transplantation.
  • Granulocyte-colony stimulating factor (G-CSF) +/- chemotherapy is standard for stem cell mobilization.
  • Some patients, particularly heavily pretreated ones, exhibit poor stem cell mobilization response.

Purpose of the Study:

  • To review current stem cell mobilization methods.
  • To explore recent advances in understanding hematopoietic stem cell (HSC) trafficking.
  • To examine the bone marrow microenvironment's role in stem cell biology.

Main Methods:

  • Literature review of stem cell mobilization techniques.
  • Analysis of recent research on HSC trafficking mechanisms.
  • Examination of the bone marrow niche and its influence on stem cells.

Main Results:

  • PBSC mobilization is the current standard, replacing bone marrow.
  • G-CSF is the primary mobilization agent, but response varies.
  • Understanding HSC trafficking is key to improving mobilization.

Conclusions:

  • Current mobilization methods are not universally effective.
  • Further research into HSC biology and the bone marrow microenvironment is needed.
  • Developing novel mobilizing agents could benefit non-responsive patients.