Related Experiment Video
Updated: Jan 27, 2026
07:28
Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
Published on: July 2, 2018
9.5K
Interference: an alteRNAtive therapy following acute myocardial infarction
Michael Monaghan1, Udo Greiser, J Gerard Wall
1Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland.
Trends in Pharmacological Sciences
|October 17, 2012
Summary
RNAi therapy shows promise for treating myocardial infarction (MI) by targeting genomic and proteomic changes. This review explores current RNAi approaches and delivery systems for the heart, aiming for clinical translation.
Area of Science:
- Cardiovascular Research
- Molecular Medicine
- Pharmacology
Background:
- Myocardial infarction (MI) triggers complex genomic and proteomic responses.
- RNA interference (RNAi) therapy is a promising pharmacological approach.
- Clinical applications of RNAi exist in other diseases, but not yet for MI.
Purpose of the Study:
- To review current RNAi therapeutic strategies for myocardial infarction.
- To examine tissue-specific delivery systems for RNAi in cardiac tissue.
- To discuss considerations for non-viral delivery to the infarcted myocardium.
Main Methods:
- Literature review of preclinical and clinical studies on RNAi for MI.
- Analysis of existing RNAi delivery systems and their suitability for cardiac applications.
- Evaluation of non-viral delivery methods for targeting the infarcted heart.
Main Results:
- RNAi therapy has demonstrated preclinical efficacy in MI models.
- Various delivery systems are being investigated for targeted RNAi delivery to the heart.
- Non-viral delivery methods show potential for improved safety and efficacy.
Conclusions:
- RNAi therapy holds significant potential as a future pharmacological intervention for MI.
- Advancements in tissue-specific delivery systems are crucial for clinical translation.
- Further research into optimized non-viral delivery is needed for effective MI treatment.
Related Concept Videos
02:18Interference and Diffraction
52.0K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.0K
01:23RNA Interference
27.9K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
27.9K
02:18Alternative RNA Splicing
24.8K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.8K
02:18Alternative RNA Splicing
5.0K
No description available
5.0K
01:16Interference and Decay
449
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
449
01:16Null and Alternative Hypotheses
12.5K
The actual hypothesis testing begins by considering two hypotheses. They are termed the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
12.5K