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Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher

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Diminished ciliary muscle movement on accommodation in myopia.

Sohee Jeon¹, Won Ki Lee, Kook Lee

¹Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Republic of Korea.

Experimental Eye Research

|October 17, 2012

Summary

Thickened ciliary muscle, potentially due to hypertrophy, may contribute to myopia development and progression by affecting eye growth and function. This preliminary study found increased ciliary muscle thickness is linked to axial length in individuals with myopia.

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Inducement and Evaluation of a Murine Model of Experimental Myopia

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

Area of Science:

Ophthalmology
Biomedical Engineering

Background:

Myopia, or nearsightedness, is a growing global health concern.
The role of the ciliary muscle in myopia development is increasingly recognized.
Speculation suggests a thickened ciliary muscle may restrict equatorial growth, contributing to myopia.

Purpose of the Study:

To investigate the relationship between ciliary muscle characteristics and myopia.
To evaluate how ciliary muscle parameters correlate with axial length and refractive error.

Main Methods:

Ultrasound biomicroscopy (UBM) was used to examine ciliary muscle characteristics in 31 volunteers (aged 19-35).
Measurements included ciliary muscle cross-sectional area, length, thickness at various points, maximum thickness, and apical angle.
Regression analyses (univariate and multivariate) were performed to assess relationships with axial length and refractive error.

Main Results:

Axial length showed a positive correlation with ciliary muscle length from the scleral aspect (CMLs) and thickness at 3.0 mm posterior to the scleral spur (CMT3).
A negative correlation was observed between axial length and changes in maximum ciliary muscle thickness (ΔCMTm) and changes in apical angle (Δapical angle).
Multivariate analysis identified ΔCMTm as an independent predictor of axial length, and a negative correlation between maximum ciliary muscle thickness (CMTm) and ΔCMTm was noted.

Conclusions:

Accentuated ciliary muscle thickness, indicative of hypertrophy, may be associated with inherent dysfunction in myopia.
These findings suggest a potential mechanism for myopia progression linked to ciliary muscle morphology.
Further research is needed to validate these preliminary findings and their implications for myopia management.