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In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

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Published on: September 16, 2021

Elective single-embryo transfer in oocyte donation programmes: Should it be the rule?

Elisabet Clua1, Rosa Tur, Buenaventura Coroleu

  • 1Servei de Medicina de la Reproducció, Departament d'Obstetrícia, Ginecologia i Reproducció, Institut Universitari Dexeus, Barcelona, Spain. eliclu@dexeus.com

Reproductive Biomedicine Online
|October 17, 2012
PubMed
Summary

Single embryo transfer (SET) in oocyte donation programs offers similar cumulative pregnancy and live birth rates compared to double embryo transfer (DET). SET significantly reduces multiple pregnancies, enhancing maternal and infant safety.

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Oocyte Donation

Background:

  • Oocyte donation programs aim to maximize pregnancy and live birth rates.
  • Balancing success rates with the risks of multiple pregnancies is crucial.

Purpose of the Study:

  • To compare cumulative clinical pregnancy and live birth rates between single-embryo transfer (SET) and double-embryo transfer (DET).
  • To evaluate the incidence of multiple pregnancies in SET versus DET within oocyte donation programs.

Main Methods:

  • Retrospective analysis of 1139 recipient fresh cycles with at least three available embryos.
  • Comparison of outcomes between SET and DET groups, including clinical pregnancy, live birth, and multiple pregnancy rates.
  • Kaplan-Meier survival analysis to assess cumulative rates over one year.

Main Results:

  • Clinical pregnancy rates were similar: 45.5% for SET and 57.1% for DET.
  • Multiple pregnancy rates were 0% for SET and 39.5% for DET.
  • Cumulative clinical pregnancy and live birth rates showed no significant difference between SET and DET over one year.

Conclusions:

  • Single embryo transfer (SET) is a viable strategy in oocyte donation programs when multiple embryos are available.
  • SET achieves comparable success rates to DET while effectively avoiding the risks associated with multiple pregnancies.
  • Prioritizing SET can improve safety outcomes for both mother and child in oocyte donation cycles.