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Updated: May 17, 2026
13:45
Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Merkel cell carcinoma. A review
Richard Pink1, Jiri Ehrmann, Martin Molitor
1Department of Oral and Maxillofacial Surgery, University Hospital Olomouc, Czech Republic. richard.pink@seznam.cz
Summary
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Early detection and combination therapy, including surgery and radiotherapy, are crucial for managing this potentially fatal disease.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with increasing incidence and high lethality.
- Its benign appearance can delay diagnosis due to extensive microscopic invasion.
- Associated with Merkel cell polyomavirus, particularly in younger immunosuppressed individuals.
Purpose of the Study:
- To review the history, epidemiology, etiology, clinical and histological features, treatment, and prognosis of Merkel cell carcinoma (MCC).
Main Methods:
- Literature search of PubMed (1972-2010).
- Keywords: Merkel cell carcinoma (MCC), etiology, treatment.
Main Results:
- MCC is a rare malignancy with an uncertain prognosis.
- Optimal treatment lacks consensus due to limited randomized studies.
- Recommended approaches include radical surgery, lymph node management, and adjuvant radiotherapy.
Conclusions:
- Early diagnosis and prompt combination therapy are vital for successful MCC management.
- Prevention through regular dermatological examination in immunosuppressed patients is key.
- Treatment involves radical surgery, radiotherapy, and potentially palliative chemotherapy.
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