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Microalbuminuria: a potential prognostic marker for acute stroke
C Gumbinger1, M Sykora, J Diedler
1Department of Neurology, University of Heidelberg, Ruprecht-Karls University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. christoph.gumbinger@med.uni-heidelberg.de
Der Nervenarzt
|October 17, 2012
Summary
Microalbuminuria (MA) is common in acute stroke patients and predicts poor outcomes. This finding highlights MA as a crucial factor for stroke prognosis and management.
Area of Science:
- Neurology
- Nephrology
- Cardiology
Background:
- Stroke is preventable by managing risk factors.
- Microalbuminuria (MA) is increasingly recognized as a chronic disease risk factor.
- The prognostic value of MA in acute stroke patients requires further investigation.
Purpose of the Study:
- To determine the prognostic significance of microalbuminuria (MA) in patients experiencing acute ischemic stroke.
- To identify predictors of poor outcomes in acute stroke patients.
Main Methods:
- Acute ischemic stroke patients were analyzed.
- Clinical history, vascular risk factors, stroke severity (NIHSS), and functional status (mRS) were recorded.
- 24-hour urinary albumin excretion was measured, and multivariate analysis identified outcome predictors.
Main Results:
- Microalbuminuria (MA) was present in 43% of patients and associated with diabetes, atrial fibrillation, higher blood pressure, and greater stroke severity.
- MA, premorbid mRS, and admission NIHSS independently predicted poor outcomes.
- MA was linked to elevated C-reactive protein (CRP) and baseline glucose levels.
Conclusions:
- Microalbuminuria (MA) is prevalent in acute ischemic stroke and predicts poor functional outcomes.
- MA serves as an independent predictor of adverse outcomes in acute stroke.
- The association of MA with CRP suggests a potential role for inflammation in acute stroke prognosis.
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