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Related Concept Videos

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: May 17, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

Erythrocyte deformability and psoriasis.

Amparo Vayá1, Belinda Andino, Jose M Ricart

  • 1Hemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain.

Clinical Hemorheology and Microcirculation
|October 17, 2012
PubMed
Summary
This summary is machine-generated.

Patients with psoriasis do not show impaired erythrocyte deformability, suggesting this rheological factor is not responsible for their increased cardiovascular risk. This finding impacts understanding of psoriasis-related cardiovascular complications.

Keywords:
Psoriasiserythrocyte deformability

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Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
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Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

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Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Rheology

Background:

  • Psoriasis is a systemic immune disorder linked to higher cardiovascular risk.
  • The role of rheological alterations, specifically erythrocyte deformability, in this increased risk is not well understood.

Purpose of the Study:

  • To investigate erythrocyte deformability in patients with psoriasis.
  • To determine if impaired erythrocyte function contributes to the cardiovascular risk associated with psoriasis.

Main Methods:

  • Erythrocyte deformability was measured using the Rheodyn SSD in 91 psoriasis patients and 101 controls.
  • Hematological, biochemical, and inflammatory markers were also assessed.

Main Results:

  • Psoriasis patients had higher BMI, triglycerides, C-reactive protein, and neutrophil counts, with lower HDL-cholesterol.
  • No significant differences in erythrocyte elongation index or deformability at tested shear stresses were found between patients and controls.

Conclusions:

  • Psoriasis patients do not exhibit impaired erythrocyte deformability.
  • Erythrocyte deformability does not appear to be a contributing factor to the elevated cardiovascular risk observed in psoriasis.