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Updated: May 17, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Synthesis of bioreducible polycations with controlled topologies
Ye-Zi You1, Jun-Jie Yan, Zhi-Qiang Yu
1CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, People's Republic of China. yzyou@ustc.edu.cn
Abstract:
Bioreducible polycations, which possess disulfide linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.
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